Hazard Ratio: Benjamin Ryan

Hazard Ratio: Benjamin Ryan

How Gordon Guyatt's 'Values and Preferences' Triggered His Fall From Grace

The "godfather of evidence-based medicine" shocked and appalled skeptics of pediatric gender medicine by adopting activist rhetoric last month that contradicted his own team's research.

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Benjamin Ryan
Sep 04, 2025
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Dr. Gordon Guyatt, a professor at McMaster University in Ontario and a titan in the field of evidence-based medicine, who recently capitulated to pressure from transgender activists.

This Substack serves as an addendum to the article I published Tuesday in

UnHerd
, which I encourage you to check out. In that investigative effort, I plumb the depths of the sprawling scandal concerning Dr. Gordon Guyatt, one of the so-called “godfathers of evidence-based medicine.” Dr. Guyatt shocked and appalled skeptics of pediatric gender medicine on Aug. 14 when he and four of his colleagues at McMaster University in Canada published a statement in which they caved to transgender-activist pressure and took sides in the political debate over the U.S. bans on puberty blockers and cross-sex hormones for minors.

Earlier this year, the Guyatt team published a trio of systematic literature reviews that found that gender-transition treatments and mastectomies for youths were all based on weak and uncertain evidence

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